miRNA-21 improve myocardial damage induced by Ischemia-reperfusion by regulation PTEN
Abstract: miRNAs are rich in myocardial cells, involved in myocardial apoptosis, arrhythmia, myocardial hypertrophy and heart failure. In this study, we found that miRNA-21 over-expression had effects to improve myocardial pathology and myocardial apoptosis which induced by Ischemia-reperfusion in vitro. We found that PTEN was a direct target of miRNA-21 in myocardial damage induced by Ischemia-reperfusion. Meanwhile, miRNA-21 regulated the PTEN/AKT/ERK/P21 pathway. Our results suggested that miRNA-21 over-expression has effects to improve myocardial damage induced by Ischemia-reperfusion by targeting PTEN.