miRNA-221 knockdown suppress cell proliferation and cell cycle in cervical cancer

Author(s): Yingqiang Ren, Yong Yang, Yuanfang Pu*

Abstract: miRNA-221 was a carcinogenic factor in many cancers, however, it is limited that the correlation between miRNA-221 and progression of cervical cancer. So we here aimed to determine the function of miRNA-221 in cervical cancer proliferation and apoptosis. Interestingly, we found that the miRNA-221 was significantly up-regulation in cervical cancer tissues. miRNA-221 knockdown inhibited the cell proliferation and improved the cell apoptosis of cervical cancer cells. Further, miRNA-221 down-regulation suppressed the activation of PI3K and AKT, and stimulated PTEN and P16 proteins expression. Together, our results suggested that miRNA-221 knockdown had suppressed the cell proliferation and stimulated cell apoptosis via PTEN/PI3K/AKT/P16 signaling pathway.

Key words: miRNA-221, cervical cancer, PTEN, P16
Adv.Bio.Med.: 2018, Vol.3(No.2),pp:3-17